Biojournal of Science and Technology

A Scholarly Journal for Biological Publications

Biojournal of Science and Technology
Volume 6, P-ISSN:2412-5377, E-ISSN:2410-9754, Article ID:m180001

Research Article

Rate of DNA Damage in Bangladeshi Preeclampsia Patients

Md. Bayejid Hosen1, 2, Abdullah Zubayer1, Yearul Kabir1 and M Zakir Hossain Howlader1*

1Department of Biochemistry and Molecular Biology, University of Dhaka, Bangladesh

2National Forensic DNA Profiling Laboratory, Dhaka Medical College Campus, Bangladesh

Date of Acceptance: Wednesday, December 5, 2018
Date of Published: Monday, December 17, 2018

Address corresponds to

M Zakir Hossain Howlader, Ph.D.

Professor

Department of Biochemistry and Molecular Biology

University of Dhaka

Dhaka – 1000

Bangladesh

Email: hhzakir@yahoo.com

Acedemic Editor: Editor-in-Chief

To cite this article
Md. Bayejid Hosen, Abdullah Zubayer, Yearul Kabir and M Zakir Hossain Howlader* .Rate of DNA Damage in Bangladeshi Preeclampsia Patients.Biojournal of Science and Technology.Volume 6,2018

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ABSTRACT

Preeclampsia (PE) is a leading cause of perinatal morbidity and mortality. Our aim of the study was to evaluate the association of DNA damage rate with preeclampsia. The study comprises a total of 52 subjects including PE women (n=27) and uncomplicated pregnant women (n=25) matched by age. DNA damage rate was measured by single-cell gel electrophoresis commonly known as comet assay. The percentage of head DNA was significantly higher in normal pregnant women compared (p< 0.001) to PE women. On the other hand, the percentage of tail DNA was significantly higher in PE women compared (p< 0.001) to normal pregnant women. There was a negative correlation (r = -0.5; p< 0.01) between head, DNA and gestational age which indicates that preeclampsia in third trimester causes more DNA damage. Therefore, evaluation of DNA damage rate may be a useful tool for diagnosis and treatment of preeclampsia during pregnancy.

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