Effects of vitamin D and Ca on the occurrence of myocardial infarction in Bangladesh

Myocardial infarction (MI), which is the most important manifestation of coronary artery disease, is the leading cause of morbidity and mortality in the world. The aim of the present study was to find out the association of vitamin D and calcium (Ca) with the risk of myocardial infarction in Bangladeshi population. A case-control study on 100 cardiac patients who has experienced MI one or more times and 150 control subjects was conducted. The serum troponin I and Ca levels were measured using Demension Xpand Plus Biochemistry Analyser. Vitamin D was estimated by HPLC method. Over all, we found significantly (p< 0.001) higher level of troponin I in cardiac patients when compared to the control subjects. The serum AST and ALP levels were significantly (p< 0.001, respectively) higher in patients when compared to controls. The level of vitamin D and Ca were also significantly lower (p< 0.001, respectively) in patients. There were significantly negative correlations between Troponin I and Vitamin D as well as Ca (r=-0.68, p< 0.001 and r=-0.27, p< 0.05, respectively) levels were found while between Vitamin D and Ca correlated (r=0.43, p< 0.01) positively. Thus our recent study suggested that may have Vitamin D & C and Ca a significant association with the occurrence of myocardial infarction.