Biojournal of Science and Technology
Volume 1, P-ISSN:2412-5377, E-ISSN:2410-9754, Article ID:m140002
In silico miRNA Target Identification within the Human Peroxisome Proliferator -Activated Receptor Gamma (PPARG) Gene
Sudip Paul*, Moumoni Saha, Kazi Saiful Islam, Md. Yeashin Gazi, Sohel Ahmed
Jahangirnagar University, Savar, Dhaka 1342, Bangladesh
Date of Acceptance: Wednesday, August 13, 2014
Date of Published: Thursday, September 25, 2014
Address corresponds to
Sudip Paul, Dept. of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh. Mob: 01674389745. e-mail: sudippaul.bcmb@gmail.com
Acedemic Editor: Dr Mohammad Nazmul Ahsan
To cite this article
Sudip Paul*, Moumoni Saha, Kazi Saiful Islam, Md. Yeashin Gazi, Sohel Ahmed
.In silico miRNA Target Identification within the Human Peroxisome Proliferator -Activated Receptor Gamma (PPARG) Gene.Biojournal of Science and Technology.Volume 1,2014
Full Text | Download manuscript | Download Citation | Views: 3124
ABSTRACT
MicroRNAs (miRNAs), an abundant class of 21-25 nucleotides long non-coding RNAs, regulate eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA- related genetic alterations are possibly more implicated in human diseases than currently appreciated. miRNA target prediction using bioinformatics tools is often the first line approach in studying gene regulation. Such predictions will help in setting search priorities for experimental validation of gene controlling mechanisms. But finding a functional miRNA target in the human genome yet remains a challenging task. In the present study, miRNA target sites within the complete sequences (5′ UTR, CDS and 3′ UTR) of human PPARG gene were investigated using miRwalk database. We found 26, 52 and 85 different miRNA target sites within the 5′ UTR, CDS and 3′ UTR regions of the gene, respectively. This computational approach will subsequently allow better in vitro confirmation of the miRNA regulatory networks in cellular systems.

p-ISSN 2412-5377
e-ISSN 2410-9754
IBI Factor 2015: 3.76
Open access-All articles published in the BJST are available for everyone to read and download upon publication with no subscription charges or registration barriers. A forum for authors, readers and other groups are also available.
Flexibility- As BJST is an online journal therefore authors can publish large datasets, large quantities of figures, video, and link of other online resources.
No Article Processing charge or Publication fee.